Patsy Walker (Trish) is one of Marvel's oldest characters. Originally a teen model, she was later revamped as the superhero Hellcat. Rachael Taylor who plays the role had a brief stint as a model herself before entering acting.
The world of the show was originally going to be closer to that of the comic, with superheroes already being a well known and established part of the universe and superpowers being much more ubiquitous. This was changed to match the more subdued Marvel Cinematic Universe, where for the most part, the only publicly known superheroes at the time were the Avengers and Daredevil. Although, the public is at least aware that there are more "gifted" individuals than just the aforementioned ones.
Trish Walker is reminded a few times about her former red hair. This is a hint from the comics, in which her superhero persona Hellcat had red hair. Other hints are given by her frequent combat training and increased security in her apartment for protection.
Jessica Jones originally appeared in the Marvel Comics series "Alias". This title was changed, of course, to avoid confusions with the unrelated series Alias (2001). However, in her home door is written 'Alias Investigations'.
Producer Melissa Rosenberg wanted to avoid actually showing rape in the story, which she called "lazy storytelling" and often a way to "spice up" male characters; she preferred to just showcase the rape-related trauma a part of the characters' everyday lives.
In episode 3 when Jessica goes into the convenience store to buy whiskey the radio host introduces one of the callers as being from Westchester, New York. Even though they are not a part of the Marvel Cinematic Universe this is where Charles Xavier's mansion is located in X-Men comics and movies.
In the Marvel comics universe, one of Jeri Hogarth's clients is the character Daniel Rand, better known as the super hero Iron Fist. Rand's father, Wendell, was a close friend of Jeri and left the execution of his estate to him (the comics version of Hogarth is male). Iron Fist is currently being developed as a series by Marvel. But if this plot will be featured is currently unknown.
When the Luke Cage movie was in its development in 2005, Jessica Jones was going to appear in it but with a major change. The character was going to be African American rather than Caucasian. Megan Goode was being considered for the part.
Since Jessica is a detective, the show producers drew influence from the film-noir genre: "the line between what's legal and what's not legal gets very blurred.... her drive is not always necessarily to solve the case, as much as it is to pay the rent and get through the day."
At least 10 versions of Jones's jacket were made, which started as an Acne Studios leather motorcycle jacket that had any "bells and whistles and any additional superfluous design details" removed, while 20 pairs of jeans were used, with both being aged and distressed.
Showrunner Melissa Rosenberg had initially expected to be inundated with viewer complaints about the abortion issue in episode "AKA You're a Winner!" (S1/E6), but instead was horrified to receive scathing condemnation for the series portrayal of a sexual relationship between a white woman and a black man - Jessica and Luke Cage. Rosenberg's picture even ended up on a 'hate site' with a Jewish star, a particularly scary moment for her as recounted to The Hollywood Reporter's Lacey Rose.
In Jessica Jones: AKA 1,000 Cuts (2015), when Simpson encounters Detective Clemons he tells him that the detective is a legend with a hell of clearance rate. In The Wire (2002), Clarke Peters' character and other detectives often complained about clearance rates and how difficult cases were distributed among themselves.
The character Will Simpson is known as the villain Nuke in the Marvel comics. He was created by one of the many secret programs trying to recreate enhanced soldiers like Captain America. His trademark face tattoo of the American flag is referenced by Simpson's lighter when he burns Clemons's body.
Royce Johnson, who starred in season one of Daredevil (2015) as Sergeant Brett Mahoney, portrays the same character in Jessica Jones: AKA Top Shelf Perverts (2015). He is the officer who tells Jessica she's been released while in police custody and later is forced to hold a gun to Detective Clemmons by Kilgrave.
After Trish tells Kilgrave's father about the combat enhancers Simpson has been taking to increase his strength and stamina, he says you "Can't grow a corresponding conscience. There's no pill for that." This is a quick reference to why Steve Rogers had originally been chosen for the 1940's super soldier program, to be augmented specifically because of his strong conscience and morality.
While investigating Antoine's disappearance in episode six, Jessica and Luke run into a group of thugs outside Antoine's house. After a short negotiation with their leader, Jessica refers to him as "Carl Icahn". Icahn is a Wall Street business man who unsuccessfully tried to gain control over Marvel in 1997, when the company was on the brink of bankruptcy.
When Simpson is given the red, white, and blue pills for the experimental "combat drugs", that is a direct relation to his character Nuke in the comic books. Nuke takes the multicolored pills for his powers.
When Jessica, Trish and Will are preparing to capture Kilgrave in episode five, Will can be seen sitting on a park bench reading a news paper with a head line mentioning Costa Verde. Costa Verde is a fictional Central American republic from the Marvel comic universe, with a turbulent history. It's most famous citizen is the super hero Silverclaw, who at one point is a member of the Avengers.
The villain Kilgrave, played by David Tennant, was known as the Purple Man in Marvel comic books. In the comic books he was born in Croatia, his given name is Zebediah Killgrave and he was a spy that had an accident with chemicals giving him permanent purple skin and his powers. In this series he's depicted as a Englishman named Kevin Thompson who gained his powers though experiments in his youth and gave himself the name Kilgrave. He has normal colored skin but wears purple throughout the series as it is his favorite color.
When Jessica uses her powers while serving a summons on Gregory Spheeris he yells "you're one of them," which could be interpreted as a reference to season three of Marvel's Agents of S.H.I.E.L.D. (2013) where some normal humans have been turning into superpowered Inhumans.
At the beginning of Jessica Jones: AKA Crush Syndrome (2015), Jessica is being interviewed in the police station after Hope has killed her parents by Detective Clemons. Jessica says she's going to Pennsylvania because of the antiques to which Det. Clemons says he likes them, too. Clarke Peters' character on The Wire (2002) also liked antiques. Also, Krysten Ritter was born in Pennsylvania.